Is Los Santos in GTA 6?
The direct answer
No. GTA 6 is set entirely in the new state of Leonida — Los Santos and San Andreas do not return.
GTA 6 moves the series to a brand-new fictional setting, Rockstar’s take on Florida, built around Vice City and five surrounding regions. There’s no confirmed connection or crossover with GTA 5’s Los Santos and Blaine County map.
This continues the series’ long-standing pattern of a full map reset with each new mainline entry — GTA 5 didn’t reuse GTA IV’s Liberty City either. Story-wise, characters may reference past locations as lore, but there’s no indication Los Santos is a visitable or returning location in GTA 6.